Linked Life Data

6626201

Source:http://linkedlifedata.com/resource/pubmed/id/6626201

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1983-11-23
pubmed:abstractText
In spite of the extensive use of isolated perfused liver systems for bile acid related studies, the composition of biliary bile acids during liver perfusion is not well known. Using recently developed bioluminescence assays for 3 alpha-OH-, 7 alpha-OH-, and 12 alpha-OH- bile acids we studied the hydroxylation pattern of bile acids in bile during 90 minutes perfusion of isolated rat liver without added bile acid load. At the beginning 7 alpha-hydroxylated bile acids comprised more than 50% of total bile acids from male livers and more than 90% from female livers, this percentage declined rapidly during the first 40-50 minutes of perfusion to values between 10 and 20%. 12 alpha-hydroxylated bile acids comprised between 15 and 30% of the total at beginning of the perfusion and decreased to about 10% after 40 minutes. Sex differences as well as the influence of the duration of perfusion should be considered when the isolated perfused rat liver is used for bile acid related studies.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0006-291X
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
115
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
518-24
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Changes of the pattern of biliary bile acids during isolated rat liver perfusion.
pubmed:publicationType
Journal Article