| pubmed-article:6625345 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6625345 | lifeskim:mentions | umls-concept:C0003947 | lld:lifeskim |
| pubmed-article:6625345 | lifeskim:mentions | umls-concept:C0085236 | lld:lifeskim |
| pubmed-article:6625345 | lifeskim:mentions | umls-concept:C0008013 | lld:lifeskim |
| pubmed-article:6625345 | lifeskim:mentions | umls-concept:C0004048 | lld:lifeskim |
| pubmed-article:6625345 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:6625345 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:6625345 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:6625345 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:6625345 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:6625345 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:6625345 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:6625345 | pubmed:dateCreated | 1983-11-23 | lld:pubmed |
| pubmed-article:6625345 | pubmed:abstractText | Alveolar macrophage supernatants from 2 groups of asbestos-exposed rats and a group of sham-exposed rats were tested for chemoattractant activity towards rat alveolar macrophages. Enhanced chemotaxin release was observed in culture supernatants from both crocidolite and chrysotile asbestos-exposed rats when compared with supernatants from sham-exposed rats. These between-group differences persisted for as long as 15 months after exposure had ceased. Chemotactic factor release was maximal after 24 h of culture in all animal groups. Partial characterization of the chemoattractant from each of the 3 rat groups revealed that it was thermolabile, nondialyzable, and trypsin-sensitive. Separation on SDS-polyacrylamide gel electrophoresis revealed 3 major peaks of activity. The production of the chemotaxin in supernatants from asbestos-exposed rats was partially inhibited by both actinomycin D and puromycin. These agents had no appreciable effect on the production of chemoattractant in cultures from sham-exposed animals. The enhanced release of an alveolar macrophage chemoattractant after asbestos inhalation may explain why macrophages accumulate at sites of asbestos deposition in the lungs. | lld:pubmed |
| pubmed-article:6625345 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6625345 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6625345 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:6625345 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6625345 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:6625345 | pubmed:issn | 0003-0805 | lld:pubmed |
| pubmed-article:6625345 | pubmed:author | pubmed-author:KaganEE | lld:pubmed |
| pubmed-article:6625345 | pubmed:author | pubmed-author:HartmannD PDP | lld:pubmed |
| pubmed-article:6625345 | pubmed:author | pubmed-author:OghisoYY | lld:pubmed |
| pubmed-article:6625345 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6625345 | pubmed:volume | 128 | lld:pubmed |
| pubmed-article:6625345 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6625345 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6625345 | pubmed:pagination | 680-7 | lld:pubmed |
| pubmed-article:6625345 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:6625345 | pubmed:year | 1983 | lld:pubmed |
| pubmed-article:6625345 | pubmed:articleTitle | Enhanced release of a chemoattractant for alveolar macrophages after asbestos inhalation. | lld:pubmed |
| pubmed-article:6625345 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6625345 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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