Linked Life Data

6622507

Source:http://linkedlifedata.com/resource/pubmed/id/6622507

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1983-11-23
pubmed:abstractText
Rats were implanted bilaterally with electrodes aimed at the medial forebrain bundle (MFB) and trained to deliver intracranial stimulation. Reward thresholds were determined using a modification of the psychophysical method of limits. Levonantradol, a cannabinoid with reported analgesic activity, was tested at doses between 0.0125 to 0.3 mg/kg. Significant elevations of reward thresholds were observed at 0.2 and 0.3 mg/kg. Since none of the doses tested lowered the reward threshold, an effect believed to be predictive of abuse, these results suggest that levonantradol has little or no abuse liability.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0091-3057
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
149-51
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
The effects of levonantradol on rewarding brain stimulation thresholds in the rat.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.