Linked Life Data

6622297

Source:http://linkedlifedata.com/resource/pubmed/id/6622297

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1983-11-23
pubmed:abstractText
Plasma and brain levels of imipramine (IMI) and desmethylimipramine (DMI) in rats after single and multiple iv administration were estimated. IMI accumulated only in plasma, while DMI accumulated in plasma and brain of rats. The brain level of IMI and DMI was higher than plasma level. After multiple administration plasma DMI concentration was significantly greater than IMI concentration. It seems that IMI was obtained steady-state plasma concentration already at fifth day of multiple administration. High dose of IMI (10 mg/kg) caused that the relationship between steady-state concentration and dose of IMI cannot be expressed as a linear function.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0301-0244
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
151-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Pharmacokinetics of imipramine after single and multiple intravenous administration in rats.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't