Linked Life Data

6620850

Source:http://linkedlifedata.com/resource/pubmed/id/6620850

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1983-11-23
pubmed:abstractText
Experiments were performed using a variety of methods to assess the functional status of different nephron populations following 45 min of renal ischemia in the rat. Micropuncture techniques revealed that SNGFR and reabsorption in the surface nephrons are only modestly reduced after ischemia, whereas kidney GFR and reabsorption are more severely affected. Determinations of bolus velocity with the Hanssen technique or of glomerular blood flow with the microsphere method confirmed that both were highest in the surface nephrons, lower in the middle nephrons and lowest of all in the juxtamedullary nephrons after ischemia. It is concluded that surface nephron function is well-maintained following ischemia and that it is the functional deficiency of the deeper nephrons that is predominantly responsible for the impairment in whole kidney function. Although the pathogenic mechanism is not yet clear, neither tubular obstruction nor tubular leakage in the deeper nephrons seems to be involved. The present findings suggest that micropuncture of the surface nephrons is a technique of questionable validity for studying this type of acute renal failure, they explain the inability of the kidney to concentrate the final urine, and they predict a more pronounced deficiency in medullary than in outer cortical blood flow.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0085-2538
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
27-36
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Disparity between surface and deep nephron function early after renal ischemia.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't