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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5661
|
pubmed:dateCreated |
1978-8-14
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pubmed:abstractText |
Tissue culture plastic adhesivity was precisely varied by applying different concentrations of poly(2-hydroxyethyl methacrylate). The extent of cell spreading was thus accurately controlled so that cells cultured on these substrata could be held at any one of a graded series of quantitated cell shapes. Cell shape was found to be tightly coupled to DNA synthesis and growth in nontransformed cells. These findings suggest a mechanism that is important in growth control of mammalian cells, and provide a more fundamental interpretation of such phenomena as density dependent inhibition of cell growth and anchorage dependence.
|
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
|
pubmed:issn |
0028-0836
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
1
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pubmed:volume |
273
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
345-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:661946-Cell Adhesion,
pubmed-meshheading:661946-Cell Cycle,
pubmed-meshheading:661946-Cell Division,
pubmed-meshheading:661946-Cell Transformation, Neoplastic,
pubmed-meshheading:661946-Cells, Cultured,
pubmed-meshheading:661946-Contact Inhibition,
pubmed-meshheading:661946-Culture Media,
pubmed-meshheading:661946-DNA,
pubmed-meshheading:661946-Growth Substances,
pubmed-meshheading:661946-Polyhydroxyethyl Methacrylate
|
pubmed:year |
1978
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pubmed:articleTitle |
Role of cell shape in growth control.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|