| pubmed-article:6619100 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6619100 | lifeskim:mentions | umls-concept:C1027142 | lld:lifeskim |
| pubmed-article:6619100 | lifeskim:mentions | umls-concept:C0025519 | lld:lifeskim |
| pubmed-article:6619100 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:6619100 | lifeskim:mentions | umls-concept:C0058372 | lld:lifeskim |
| pubmed-article:6619100 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:6619100 | lifeskim:mentions | umls-concept:C0301869 | lld:lifeskim |
| pubmed-article:6619100 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:6619100 | pubmed:dateCreated | 1983-11-23 | lld:pubmed |
| pubmed-article:6619100 | pubmed:abstractText | Biphenyl metabolism in Aspergillus toxicarius occurs by successive hydroxylations in the 4- and 4'-positions, followed by conjugation with sulfate to produce 4-hydroxybiphenyl-O-sulfonic acid and 4,4'-dihydroxybiphenyl-O-sulfonic acid. The hydroxylation reactions normally occur only after a prolonged lag period after which the appearance of the monohydroxylated compound precedes the dihydroxylated compound. The accumulation of the monohydroxy compound is transient; therefore, it is an intermediate in the hydroxylating pathway. The onset of hydroxylating activity can be greatly accelerated when the culture is primed with the intermediate or product of the reaction (4-hydroxybiphenyl or 4,4'-dihydroxybiphenyl) at the time of biphenyl addition; a concentration of 0.05 mg 4,4'-dihydroxybiphenyl per ml produces optimal induction. Water-soluble conjugates of 4-hydroxybiphenyl and 4,4'-dihydroxybiphenyl were found in cultures of A. toxicarius grown in the presence of biphenyl plus inducer. The conjugate was shown to be the sulfate ester; no glucuronide or other conjugate species was found in any phase of the transformation. As with hydroxylating activity, the sulfotransferase activity appeared to be induced by the products of biphenyl metabolism. | lld:pubmed |
| pubmed-article:6619100 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:6619100 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6619100 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:6619100 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6619100 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6619100 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6619100 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6619100 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6619100 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:6619100 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6619100 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6619100 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:6619100 | pubmed:issn | 0021-9193 | lld:pubmed |
| pubmed-article:6619100 | pubmed:author | pubmed-author:GolbeckJ HJH | lld:pubmed |
| pubmed-article:6619100 | pubmed:author | pubmed-author:RadmerRR | lld:pubmed |
| pubmed-article:6619100 | pubmed:author | pubmed-author:AlbaughS ASA | lld:pubmed |
| pubmed-article:6619100 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6619100 | pubmed:volume | 156 | lld:pubmed |
| pubmed-article:6619100 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6619100 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6619100 | pubmed:pagination | 49-57 | lld:pubmed |
| pubmed-article:6619100 | pubmed:dateRevised | 2010-9-10 | lld:pubmed |
| pubmed-article:6619100 | pubmed:meshHeading | pubmed-meshheading:6619100-... | lld:pubmed |
| pubmed-article:6619100 | pubmed:meshHeading | pubmed-meshheading:6619100-... | lld:pubmed |
| pubmed-article:6619100 | pubmed:meshHeading | pubmed-meshheading:6619100-... | lld:pubmed |
| pubmed-article:6619100 | pubmed:meshHeading | pubmed-meshheading:6619100-... | lld:pubmed |
| pubmed-article:6619100 | pubmed:meshHeading | pubmed-meshheading:6619100-... | lld:pubmed |
| pubmed-article:6619100 | pubmed:meshHeading | pubmed-meshheading:6619100-... | lld:pubmed |
| pubmed-article:6619100 | pubmed:year | 1983 | lld:pubmed |
| pubmed-article:6619100 | pubmed:articleTitle | Metabolism of biphenyl by Aspergillus toxicarius: induction of hydroxylating activity and accumulation of water-soluble conjugates. | lld:pubmed |
| pubmed-article:6619100 | pubmed:publicationType | Journal Article | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6619100 | lld:pubmed |
