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Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1983-11-23
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pubmed:abstractText |
The co-culture of mouse peritoneal macrophages and Lewis lung carcinoma cells induces the release of a metal-dependent type IV collagen-degrading proteinase which is not produced in detectable amounts by either cell type cultivated alone. Conditioned media of the co-cultures degrade both pepsin-extracted type IV collagen from human placenta and mouse type IV procollagen. Thus macrophages can interact with tumor cells to degrade basement membrane type IV collagen: this might be of importance to allow cancer invasion and metastasis.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0014-5793
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
161
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
243-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6617877-Animals,
pubmed-meshheading:6617877-Basement Membrane,
pubmed-meshheading:6617877-Cells, Cultured,
pubmed-meshheading:6617877-Collagen,
pubmed-meshheading:6617877-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:6617877-Humans,
pubmed-meshheading:6617877-Lung Neoplasms,
pubmed-meshheading:6617877-Macrophages,
pubmed-meshheading:6617877-Male,
pubmed-meshheading:6617877-Mice,
pubmed-meshheading:6617877-Neoplasm Metastasis,
pubmed-meshheading:6617877-Peritoneal Cavity,
pubmed-meshheading:6617877-Placenta
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pubmed:year |
1983
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pubmed:articleTitle |
Co-operation between metastatic tumor cells and macrophages in the degradation of basement membrane (type IV) collagen.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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