Linked Life Data

6617750

Source:http://linkedlifedata.com/resource/pubmed/id/6617750

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1983-11-23
pubmed:abstractText
In vagotomized dogs, lesions of the lateral reticular nucleus (LRN) region did not change arterial blood pressure and sympathetic nerve activity. The hypertensive and tachycardic responses elicited by section of both carotid sinus nerves and both vagus nerves were not altered. However the sympathoinhibitory component of the baroreflex arc was attenuated. These lesions also abolished the hypotensive and sympathoinhibitory effects of fentanyl (10 micrograms/kg i.v.). In debuffered dogs, bilateral lesions of the LRN regions attenuated the effects of fentanyl (20 micrograms/kg i.v.) on arterial blood pressure and splanchnic discharges. Microinfusion of naloxone into the LRN reduced the effects of fentanyl (10 micrograms/kg) administered intravenously. Microinfusion of [D-Ala2,Met5]enkephalinamide (0.1-1 microgram) into the LRN region produced a dose dependent decrease in arterial blood pressure and sympathetic nerve activity. Lesions of the nucleus ambiguus (NA) region also reduced the effects of fentanyl. In contrast, lesions placed in the ventral median reticular formation or above the NA were ineffective in changing the sympathoinhibitory effect of fentanyl. These results indicate that the lateral reticular formation ventral to the nucleus ambiguus including the lateral reticular nucleus region is involved in the sympathoinhibitory effect of morphinomimetic agents.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
5
pubmed:volume
91
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
431-9
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Origin of the hypotensive and sympathoinhibitory effect of morphinomimetic agents.
pubmed:publicationType
Journal Article