Linked Life Data

6617695

Source:http://linkedlifedata.com/resource/pubmed/id/6617695

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1983-11-23
pubmed:abstractText
This paper discusses the relevance of certain animal models for the production of ischaemia and reperfusion-induced ventricular arrhythmias to clinical problems of ischaemia, for example, sudden cardiac death. It then describes experiments in anaesthetised rats subjected to acute coronary artery occlusion in which nifedipine (administered both intravenously and orally) prevented the occurrence of ventricular fibrillation and markedly increased survival. In anaesthetised dogs, a continuous intravenous infusion of nifedipine reduced the severity and incidence of ventricular ectopic activity and also dramatically improved survival on reperfusion fro 12.5% (in the controls) to 88%. The mechanisms of this protection are discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0195-668X
pubmed:author
pubmed:issnType
Print
pubmed:volume
4 Suppl C
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
49-54
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Cardioprotection with calcium antagonists by suppression of early ischaemia and reperfusion-induced arrhythmias.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't