Linked Life Data

6617607

Source:http://linkedlifedata.com/resource/pubmed/id/6617607

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1983-11-23
pubmed:abstractText
The effects of oral ingestion of different pesticides (lindane, phosalone, carbaryl) and of a polychlorinated biphenyl (pyralene) on nonreaginic antibody production in BALB/c mice and also on the duration of Giardia muris infection have been studied using the animal model of this disease. Only lindane and carbaryl produced significant effects on systemic antibody production following oral immunization with sheep red blood cells (SRBC). Lindane ingestion led to a twofold increase in IgG2b antibody titer to SRBC (P less than 0.05) and carbaryl significantly increased both IgG1 and IgG2b titers. No reduction was seen in the synthesis of any antibody class. The effect of feeding with lindane was to increase the duration of giardiasis significantly (P less than 0.002), and these mice developed systemic anti-Giardia antibodies more frequently than Giardia-infected mice on normal diets. These results suggest that in the doses used these pesticides may increase systemic antibody responses to orally ingested antigens, and by inference that spontaneous elimination of giardiasis is independent of the systemic nonreaginic antibody response to the parasite.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0013-9351
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
145-50
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Pesticide-containing diets augment anti-sheep red blood cell nonreaginic antibody responses in mice but may prolong murine infection with Giardia muris.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't