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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1983-11-23
|
| pubmed:abstractText |
Midazolam kinetics were determined in 11 younger (22 to 30 yr) and 11 older (50 to 60 yr) women to determine age-related differences in the kinetics of this water-soluble benzodiazepine. Midazolam, 0.2 mg/kg, was injected intravenously over 30 sec for induction of anesthesia that was maintained with 67% nitrous oxide in oxygen and intravenous fentanyl doses. There were no differences between the groups with respect to awakening times or plasma concentrations. Midazolam kinetics were described by a three-compartment open mamillary model. The only differences were small increases in the slow and total volumes of distribution in the older women. The kinetics we determined, including the steady-state volume of distribution of 1.23 l/kg and the elimination clearance of 419 ml/min, are in excellent agreement with those reported by others. Our data suggest that midazolam has advantages over other benzodiazepines, not only because of its water solubility and shorter elimination t1/2, but also because of little change in its kinetics with age.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0009-9236
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
34
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
505-8
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading | |
| pubmed:year |
1983
|
| pubmed:articleTitle |
Midazolam kinetics in women of two age groups.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|