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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1983-10-8
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pubmed:abstractText |
Tangier disease is a rare, autosomal recessive condition characterized by cholesterol ester deposition in reticuloendothelial cells, abnormal chylomicron remnants, decreased low-density lipoprotein levels, and a marked deficiency of high-density lipoproteins. Apolipoprotein A-I, a major protein constituent of chylomicrons and high-density lipoproteins, has been shown to be structurally and metabolically abnormal in this disease (apolipoprotein A-ITangier). A 63-year-old Tangier homozygous man is described, who underwent splenectomy because of thrombocytopenia and splenomegaly. Subsequently, a large orange mass developed at the base of the mesentery, with several smaller omental masses and thickening of the entire omentum due to infiltration with lipid-laden macrophages. Splenectomy appears to predispose to such deposition, since such masses have not been observed in other Tangier homozygotes. The spleen appears to play a significant role in the removal of abnormal lipoproteins in Tangier homozygotes; therefore, splenectomy may be contraindicated in Tangier disease.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0002-9343
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
75
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
521-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6614036-Apolipoproteins,
pubmed-meshheading:6614036-Granuloma,
pubmed-meshheading:6614036-Humans,
pubmed-meshheading:6614036-Hypolipoproteinemias,
pubmed-meshheading:6614036-Kupffer Cells,
pubmed-meshheading:6614036-Lipid Metabolism,
pubmed-meshheading:6614036-Lipoproteins,
pubmed-meshheading:6614036-Macrophages,
pubmed-meshheading:6614036-Male,
pubmed-meshheading:6614036-Microscopy, Electron,
pubmed-meshheading:6614036-Middle Aged,
pubmed-meshheading:6614036-Omentum,
pubmed-meshheading:6614036-Splenectomy,
pubmed-meshheading:6614036-Tangier Disease
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pubmed:year |
1983
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pubmed:articleTitle |
Massive omental reticuloendothelial cell lipid uptake in Tangier disease after splenectomy.
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pubmed:publicationType |
Journal Article,
Case Reports
|