Linked Life Data

6613810

Source:http://linkedlifedata.com/resource/pubmed/id/6613810

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4 Pt 1
pubmed:dateCreated
1983-10-28
pubmed:abstractText
The rate and form of creatine kinase-MB (CK-MB) enzyme release following reflow to ischemic myocardium has not been specifically examined in man. In this investigation, we examined the combined CK-MB time-activity curves during acute transmural myocardial infarction (AMI) in a group of patients receiving conventional therapy (CAMI) (n = 109), and in a group of nine patients with successful reperfusion by fibrinolytic therapy (RAMI). The average time of reflow in the latter group was 4.2 +/- 1.7 hours (mean +/- SD) following the onset of symptoms. The average time-to-peak CK-MB for the CAMI group was 18.3 +/- 5.5 hours and for RAMI it was 9.9 +/- 1.1 p less than 0.001). At hour 4 (about the time of reflow), the two groups had similar CK-MB elevations (CAMI = 11 +/- 7, RAMI = 13 +/- 11 LU/L). By hour 6 (reflow + 2 hours), the RAMI CK-MB values were significantly higher (55 +/- 33 vs 20 +/- 15 IU/L, p less than 0.02) than the CAMI group, demonstrating an increase in the release rate of CK-MB associated with reperfusion. We conclude that in man, reflow to the ischemic myocardium significantly augments the release rate of CK-MB.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0002-8703
pubmed:author
pubmed:issnType
Print
pubmed:volume
106
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
665-9
pubmed:dateRevised
2006-2-27
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Effects of nonsurgical myocardial reperfusion on plasma creatine kinase kinetics in man.
pubmed:publicationType
Journal Article