Linked Life Data

6613463

Source:http://linkedlifedata.com/resource/pubmed/id/6613463

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1983-10-8
pubmed:abstractText
Intestinal vascular obstruction with an obstruction pressure of 120 cm of water for one hour induces a 75% mortality in rats. The mortality is associated with intestinal mucosal lesions, release of cardiotoxic material to the intestinal venous blood and trapping of platelets in the lungs. The present series of experiments was performed to study the role of released serotonin in the pathogenesis of the circulatory collapse that follows in this shock model. This was done by pretreating rats subjected to standardized intestinal vascular obstruction with Ketanserin, a selective 5-HT2 receptor blocking agent. It was found that Ketanserin reduced the increase in hematocrit otherwise induced but had no significant effect on mortality, trapping of platelets or the intestinal mucosal lesions. It is concluded that serotonin is probably not of significant importance in the pathogenesis of the circulatory collapse following intestinal vascular obstruction.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0001-5482
pubmed:author
pubmed:issnType
Print
pubmed:volume
149
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
273-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
The effects of 5-HT blockade in graded intestinal vascular obstruction in the rat.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't