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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8
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pubmed:dateCreated |
1984-9-7
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pubmed:abstractText |
The radioiodine-labeled amines currently available as brain-imaging agents, based on our previous work and that of others, are prepared either by exchange labeling or by direct iodination of a protected intermediate. The intrinsic slowness of these processes limits their potential for use with the positron-emitting 122I, as it has a half-life of only 3.6 min. This isotope has advantages of a low dose to the patient and availability from a generator containing the parent 20-h 122Xe. To develop a radiopharmaceutical in which 122I could be utilized, we prepared a number of secondary and tertiary amines (maintaining the 2,5-dimethoxy substitution pattern which allows direct iodination at the 4-position) with 131I. The organ distributions of these compounds were studied, and the best properties were found in the N,N-dimethyl homologue (2,5-dimethoxy-N,N-dimethyl-4-iodoamphetamine). This compound was successfully synthesized in a matter of seconds, with a chemical yield and radioactive purity both in excess of 90% and an incorporation efficiency of radioiodine of about 40%.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-2623
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1071-7
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6611416-Amphetamines,
pubmed-meshheading:6611416-Animals,
pubmed-meshheading:6611416-Brain,
pubmed-meshheading:6611416-Cerebrovascular Circulation,
pubmed-meshheading:6611416-Dogs,
pubmed-meshheading:6611416-Halogens,
pubmed-meshheading:6611416-Iodine Radioisotopes,
pubmed-meshheading:6611416-Radionuclide Generators,
pubmed-meshheading:6611416-Regional Blood Flow,
pubmed-meshheading:6611416-Tissue Distribution,
pubmed-meshheading:6611416-Tomography, Emission-Computed,
pubmed-meshheading:6611416-Xenon Radioisotopes
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pubmed:year |
1984
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pubmed:articleTitle |
Radiohalogen-labeled imaging agents. 3. Compounds for measurement of brain blood flow by emission tomography.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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