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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1984-9-13
|
| pubmed:abstractText |
We studied the ability of phytohemagglutinin (PHA) and two anti-T-cell monoclonal antibodies, OKT3 and Pan T2, to induce interleukin-2 (IL2) production and proliferation in peripheral blood lymphocytes (PBL) from 14 patients with combined varied immunodeficiency (CVI). The median values of endogenous IL2 produced by mitogen-stimulated PBL was significantly lower in patients than controls irrespective of the mitogen used. The patients, taken as a group, had a significantly decreased in vitro PBL response to mitogen stimulation when compared to controls. With the addition of a highly purified human IL2 preparation, the proliferative response in the majority of patients was significantly improved with all mitogens. Three patient groups could be distinguished: Group A (3/14) had full restoration of proliferative response with the addition of IL2, Group B (5/14) had partial restoration, and Group C (6/14) had no significant response. The monoclonal antibody, Pan T2, recognized a T-cell proliferative defect in 5 of 14 patients which neither PHA nor OKT3 recognized. This was not significantly corrected by the addition of IL2. This T-cell proliferative defect correlated with the lack of B-cell proliferation and immunoglobulin production in response to B-cell mitogens in three-fourths of the patients assayed. These data show that CVI patients are a heterogeneous group but have in common a decreased in vitro production of IL2 resulting in a proliferative defect which is correctable at least in part, in vitro, in the majority by the addition of purified IL2.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0271-9142
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
4
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
N
|
| pubmed:pagination |
295-303
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:6611349-Adolescent,
pubmed-meshheading:6611349-Adult,
pubmed-meshheading:6611349-Agammaglobulinemia,
pubmed-meshheading:6611349-Antibodies, Monoclonal,
pubmed-meshheading:6611349-Antibody-Producing Cells,
pubmed-meshheading:6611349-B-Lymphocytes,
pubmed-meshheading:6611349-Child,
pubmed-meshheading:6611349-Child, Preschool,
pubmed-meshheading:6611349-Female,
pubmed-meshheading:6611349-Humans,
pubmed-meshheading:6611349-IgA Deficiency,
pubmed-meshheading:6611349-IgG Deficiency,
pubmed-meshheading:6611349-Interleukin-2,
pubmed-meshheading:6611349-Lymphocyte Activation,
pubmed-meshheading:6611349-Male,
pubmed-meshheading:6611349-Middle Aged,
pubmed-meshheading:6611349-Mitogens,
pubmed-meshheading:6611349-T-Lymphocytes
|
| pubmed:year |
1984
|
| pubmed:articleTitle |
Interleukin-2 correction of defective in vitro T-cell mitogenesis in patients with common varied immunodeficiency.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|