Linked Life Data

6610680

Source:http://linkedlifedata.com/resource/pubmed/id/6610680

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1984-8-23
pubmed:abstractText
Butylnitrosourea (BNU) was used to induce thymic lymphomas in BDF1 mice. During and after the 12-week BNU exposure the spontaneous NK cell activity against YAC-1 cells and that arising 4 days after stimulation with Corynebacterium parvum (CP) were measured, as were the mitogen responses of splenic T and B cells. In addition to BNU, groups of mice received multiple injections of the interferon inducer CP during or after the BNU exposure period. The results show a slight impairment of the NK cell activity by BNU and also after the injections of CP depending heavily on the treatment protocol. After the multiple injections of CP, either into BNU-treated mice or into controls, no further stimulation by CP was possible. The mitogen responses, reduced after BNU, were further reduced after the additional treatment. Both effects can be explained by the known induction of suppressor cells by CP. Although these treatments had pronounced effects on the parameters tested in vitro there was no significant influence on the development of thymic lymphomas in vivo.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0171-5216
pubmed:author
pubmed:issnType
Print
pubmed:volume
107
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
199-205
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Studies on natural killer cell activity and the influence of Corynebacterium parvum on murine T-cell leukemogenesis induced by butylnitrosourea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't