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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1984-6-29
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pubmed:abstractText |
The preventive effect of rat and human fibrin sealing on intra-abdominal adhesion formation was investigated in 40 rats. Intraperitoneal adhesion formation was induced by excision of 1 X 3 cm of the peritoneal parietalmuscular layer, subsequently closed by interrupted 3-0 silk sutures. A total of 80 defects were allocated to one of four treatments: 1) the defect was covered with human fibrin sealant with the aid of a syringe. 2) the defect was covered with rat fibrin sealant with the aid of a syringe. 3) the defect was covered with human fibrin sealant with the aid of a spray. 4) the defect was not covered (control group). Assessment of the adhesion formation one week postoperatively showed that the median length of adhesions in defects covered with fibrin sealant applied by a syringe (10.5 mm) or by spray (14 mm) was less than that of the control group (25 mm) to a significantly high degree (P less than 0.001). It is concluded that fibrin sealant prevents intraperitoneal adhesion formation in the present rat model.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0355-9521
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
73
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
11-3
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:6610380-Animals,
pubmed-meshheading:6610380-Antifibrinolytic Agents,
pubmed-meshheading:6610380-Drug Combinations,
pubmed-meshheading:6610380-Factor XIII,
pubmed-meshheading:6610380-Female,
pubmed-meshheading:6610380-Fibrin,
pubmed-meshheading:6610380-Fibrin Tissue Adhesive,
pubmed-meshheading:6610380-Fibrinogen,
pubmed-meshheading:6610380-Fibronectins,
pubmed-meshheading:6610380-Humans,
pubmed-meshheading:6610380-Peritoneal Dialysis,
pubmed-meshheading:6610380-Peritoneal Diseases,
pubmed-meshheading:6610380-Postoperative Complications,
pubmed-meshheading:6610380-Rats,
pubmed-meshheading:6610380-Rats, Inbred Strains,
pubmed-meshheading:6610380-Thrombin,
pubmed-meshheading:6610380-Tissue Adhesions,
pubmed-meshheading:6610380-Tissue Adhesives
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pubmed:year |
1984
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pubmed:articleTitle |
Prevention of peritoneal adhesion formation by fibrin sealant. An experimental study in rats.
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pubmed:publicationType |
Journal Article,
Comparative Study
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