Linked Life Data

6610078

Source:http://linkedlifedata.com/resource/pubmed/id/6610078

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1984-6-28
pubmed:abstractText
The in vitro conversion of the synthetic steroidal androgen methyltrienolone (17 beta-hydroxy-17 alpha- methylestra -4,9,11-trien-3-one) to an estrogen was investigated. First, with a placental microsome preparation a 10-fold molar excess of methyltrienolone did not affect the aromatization of testosterone. Therefore, methyltrienolone did not compete with testosterone in this very active aromatase system, nor did it inhibit the aromatization. Second, while the placental aromatase very efficiently converted testosterone to estrogens, it did not convert methyltrienolone [3H] to estrogenic (phenolic) products. Third, homogenates of rat hypothalamic tissue were also unable to aromatize methyltrienolone, although they converted small quantities of testosterone to estradiol and 19-hydroxyandrostenedione to estrone. This lack of aromatization of methyltrienolone is consistent with observations of additional behavioral and in vivo biochemical experiments.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-4731
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1157-62
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Methyltrienolone (R1881) is not aromatized by placental microsomes or rat hypothalamic homogenates.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't