| pubmed-article:6609968 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6609968 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:6609968 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:6609968 | lifeskim:mentions | umls-concept:C0030896 | lld:lifeskim |
| pubmed-article:6609968 | lifeskim:mentions | umls-concept:C0085862 | lld:lifeskim |
| pubmed-article:6609968 | lifeskim:mentions | umls-concept:C0003261 | lld:lifeskim |
| pubmed-article:6609968 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:6609968 | lifeskim:mentions | umls-concept:C1299583 | lld:lifeskim |
| pubmed-article:6609968 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:6609968 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:6609968 | lifeskim:mentions | umls-concept:C1608386 | lld:lifeskim |
| pubmed-article:6609968 | lifeskim:mentions | umls-concept:C1549571 | lld:lifeskim |
| pubmed-article:6609968 | lifeskim:mentions | umls-concept:C0301625 | lld:lifeskim |
| pubmed-article:6609968 | lifeskim:mentions | umls-concept:C1627358 | lld:lifeskim |
| pubmed-article:6609968 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:6609968 | pubmed:dateCreated | 1984-6-27 | lld:pubmed |
| pubmed-article:6609968 | pubmed:abstractText | The effect of 2'-deoxycoformycin (DCF) on the PFC responses of AKR mice to SE, TNP-Ficoll, and TNP-B. abortus was examined. Subcutaneous injection of DCF 4 days before antigen caused suppression of all three responses by 70 to 78%. In contrast, injection of DCF 1 day after antigen caused enhancement of both the anti-SE and the anti-TNP-Ficoll responses. Although a single high dose of cortisone acetate injected 4 days before antigen caused a similar suppression, the effect of DCF was not mediated via a steroid release, inasmuch as DCF also suppressed the immune response in adrenalectomized mice. The response of BALB/c mice to TNP-Ficoll was also inhibited by DCF pretreatment and enhanced by injection of DCF after antigen. In contrast, in athymic mice DCF caused suppression of the anti-TNP-Ficoll PFC response, whether injected before or after antigen. These results are interpreted as suggesting that DCF causes suppression primarily via an effect on B cells. The enhancement seen in normal but not in athymic mice may possibly be ascribed to an effect on suppressor T cells. Apparently the enhancement of both TD and TI responses caused by DCF injected 1 day after antigen in normal mice is the net result of these two opposing effects. The results imply that helper T cells are resistant to DCF. | lld:pubmed |
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| pubmed-article:6609968 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6609968 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6609968 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:6609968 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6609968 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:6609968 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:6609968 | pubmed:author | pubmed-author:ThorbeckeG... | lld:pubmed |
| pubmed-article:6609968 | pubmed:author | pubmed-author:HirschhornRR | lld:pubmed |
| pubmed-article:6609968 | pubmed:author | pubmed-author:RatechHH | lld:pubmed |
| pubmed-article:6609968 | pubmed:author | pubmed-author:BellM KMK | lld:pubmed |
| pubmed-article:6609968 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6609968 | pubmed:volume | 132 | lld:pubmed |
| pubmed-article:6609968 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6609968 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6609968 | pubmed:pagination | 3071-6 | lld:pubmed |
| pubmed-article:6609968 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:6609968 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6609968 | pubmed:articleTitle | Effects of deoxycoformycin in mice. I. Suppression and enhancement of in vivo antibody responses to thymus-dependent and -independent antigens. | lld:pubmed |
| pubmed-article:6609968 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6609968 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6609968 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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