Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1984-6-27
pubmed:abstractText
The effect of 2'-deoxycoformycin (DCF) on the PFC responses of AKR mice to SE, TNP-Ficoll, and TNP-B. abortus was examined. Subcutaneous injection of DCF 4 days before antigen caused suppression of all three responses by 70 to 78%. In contrast, injection of DCF 1 day after antigen caused enhancement of both the anti-SE and the anti-TNP-Ficoll responses. Although a single high dose of cortisone acetate injected 4 days before antigen caused a similar suppression, the effect of DCF was not mediated via a steroid release, inasmuch as DCF also suppressed the immune response in adrenalectomized mice. The response of BALB/c mice to TNP-Ficoll was also inhibited by DCF pretreatment and enhanced by injection of DCF after antigen. In contrast, in athymic mice DCF caused suppression of the anti-TNP-Ficoll PFC response, whether injected before or after antigen. These results are interpreted as suggesting that DCF causes suppression primarily via an effect on B cells. The enhancement seen in normal but not in athymic mice may possibly be ascribed to an effect on suppressor T cells. Apparently the enhancement of both TD and TI responses caused by DCF injected 1 day after antigen in normal mice is the net result of these two opposing effects. The results imply that helper T cells are resistant to DCF.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, T-Independent, http://linkedlifedata.com/resource/pubmed/chemical/Blood Group Antigens, http://linkedlifedata.com/resource/pubmed/chemical/Coformycin, http://linkedlifedata.com/resource/pubmed/chemical/Cortisone, http://linkedlifedata.com/resource/pubmed/chemical/Ficoll, http://linkedlifedata.com/resource/pubmed/chemical/Immunosuppressive Agents, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2, http://linkedlifedata.com/resource/pubmed/chemical/Pentostatin, http://linkedlifedata.com/resource/pubmed/chemical/Ribonucleosides, http://linkedlifedata.com/resource/pubmed/chemical/TNP-ficoll, http://linkedlifedata.com/resource/pubmed/chemical/Trinitrobenzenes, http://linkedlifedata.com/resource/pubmed/chemical/cortisone acetate
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:volume
132
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3071-6
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:6609968-Adrenalectomy, pubmed-meshheading:6609968-Animals, pubmed-meshheading:6609968-Antibody Formation, pubmed-meshheading:6609968-Antigens, T-Independent, pubmed-meshheading:6609968-Blood Group Antigens, pubmed-meshheading:6609968-Coformycin, pubmed-meshheading:6609968-Cortisone, pubmed-meshheading:6609968-Drug Interactions, pubmed-meshheading:6609968-Female, pubmed-meshheading:6609968-Ficoll, pubmed-meshheading:6609968-Immunosuppressive Agents, pubmed-meshheading:6609968-Interleukin-2, pubmed-meshheading:6609968-Mice, pubmed-meshheading:6609968-Mice, Inbred AKR, pubmed-meshheading:6609968-Mice, Inbred BALB C, pubmed-meshheading:6609968-Mice, Nude, pubmed-meshheading:6609968-Pentostatin, pubmed-meshheading:6609968-Ribonucleosides, pubmed-meshheading:6609968-Sheep, pubmed-meshheading:6609968-Trinitrobenzenes
pubmed:year
1984
pubmed:articleTitle
Effects of deoxycoformycin in mice. I. Suppression and enhancement of in vivo antibody responses to thymus-dependent and -independent antigens.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't