rdf:type |
|
lifeskim:mentions |
umls-concept:C0003261,
umls-concept:C0003320,
umls-concept:C0026809,
umls-concept:C0030896,
umls-concept:C0085862,
umls-concept:C0301625,
umls-concept:C1280500,
umls-concept:C1299583,
umls-concept:C1515655,
umls-concept:C1549571,
umls-concept:C1608386,
umls-concept:C1627358,
umls-concept:C2349975
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pubmed:issue |
6
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pubmed:dateCreated |
1984-6-27
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pubmed:abstractText |
The effect of 2'-deoxycoformycin (DCF) on the PFC responses of AKR mice to SE, TNP-Ficoll, and TNP-B. abortus was examined. Subcutaneous injection of DCF 4 days before antigen caused suppression of all three responses by 70 to 78%. In contrast, injection of DCF 1 day after antigen caused enhancement of both the anti-SE and the anti-TNP-Ficoll responses. Although a single high dose of cortisone acetate injected 4 days before antigen caused a similar suppression, the effect of DCF was not mediated via a steroid release, inasmuch as DCF also suppressed the immune response in adrenalectomized mice. The response of BALB/c mice to TNP-Ficoll was also inhibited by DCF pretreatment and enhanced by injection of DCF after antigen. In contrast, in athymic mice DCF caused suppression of the anti-TNP-Ficoll PFC response, whether injected before or after antigen. These results are interpreted as suggesting that DCF causes suppression primarily via an effect on B cells. The enhancement seen in normal but not in athymic mice may possibly be ascribed to an effect on suppressor T cells. Apparently the enhancement of both TD and TI responses caused by DCF injected 1 day after antigen in normal mice is the net result of these two opposing effects. The results imply that helper T cells are resistant to DCF.
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pubmed:grant |
|
pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, T-Independent,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Group Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Coformycin,
http://linkedlifedata.com/resource/pubmed/chemical/Cortisone,
http://linkedlifedata.com/resource/pubmed/chemical/Ficoll,
http://linkedlifedata.com/resource/pubmed/chemical/Immunosuppressive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Pentostatin,
http://linkedlifedata.com/resource/pubmed/chemical/Ribonucleosides,
http://linkedlifedata.com/resource/pubmed/chemical/TNP-ficoll,
http://linkedlifedata.com/resource/pubmed/chemical/Trinitrobenzenes,
http://linkedlifedata.com/resource/pubmed/chemical/cortisone acetate
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-1767
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:volume |
132
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3071-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6609968-Adrenalectomy,
pubmed-meshheading:6609968-Animals,
pubmed-meshheading:6609968-Antibody Formation,
pubmed-meshheading:6609968-Antigens, T-Independent,
pubmed-meshheading:6609968-Blood Group Antigens,
pubmed-meshheading:6609968-Coformycin,
pubmed-meshheading:6609968-Cortisone,
pubmed-meshheading:6609968-Drug Interactions,
pubmed-meshheading:6609968-Female,
pubmed-meshheading:6609968-Ficoll,
pubmed-meshheading:6609968-Immunosuppressive Agents,
pubmed-meshheading:6609968-Interleukin-2,
pubmed-meshheading:6609968-Mice,
pubmed-meshheading:6609968-Mice, Inbred AKR,
pubmed-meshheading:6609968-Mice, Inbred BALB C,
pubmed-meshheading:6609968-Mice, Nude,
pubmed-meshheading:6609968-Pentostatin,
pubmed-meshheading:6609968-Ribonucleosides,
pubmed-meshheading:6609968-Sheep,
pubmed-meshheading:6609968-Trinitrobenzenes
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pubmed:year |
1984
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pubmed:articleTitle |
Effects of deoxycoformycin in mice. I. Suppression and enhancement of in vivo antibody responses to thymus-dependent and -independent antigens.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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