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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1984-5-2
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pubmed:abstractText |
The importance of nerve growth factor (NGF) for the development of sensory ganglia was investigated by injecting rat fetuses (16.50 days of gestation) with a single dose of anti-NGF antiserum. Four months later the treated animals showed a very large decrease in substance P- and somatostatin-like immunoreactivities in dorsal root ganglia and skin with a lesser decrease in trigeminal ganglia. Fluoride-resistant acid phosphatase, substance P-, and somatostatin-like immunoreactivities were greatly decreased in the dorsal horn of the spinal cord. No change in neurotensin- and [Met]enkephalin-like immunoreactivities was observed. The anti-NGF antiserum treatment produced a greater than 90% decrease in the number of unmyelinated dorsal root fibers and a 35% decrease in the total number of myelinated fibers. The loss in myelinated fibers was restricted to small-diameter fibers with no change in large-diameter fibers. No change in taste bud morphology was noted, thereby refuting the proposal that anti-NGF antiserum treatment may represent an animal model for familial dysautonomia. The present results indicate that NGF is a necessary requirement for the normal development of a significant population of prenatal rat dorsal root ganglion cells.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6608728-1004708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6608728-13717874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6608728-13904079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6608728-16578497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6608728-26453,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6608728-279023,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6608728-399775,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6608728-490183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6608728-492542,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6608728-4982360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6608728-5434742,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6608728-593396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6608728-6106528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6608728-6159533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6608728-6162531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6608728-6170069,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6608728-6170908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6608728-6171632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6608728-6175929,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6608728-6176904,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6608728-6182949,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6608728-6185658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6608728-6185853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6608728-6186943,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6608728-6193421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6608728-6287924,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6608728-6928668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6608728-7188352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6608728-7192014,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6608728-7242663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6608728-903796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6608728-92024,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6608728-990924
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1580-4
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6608728-Aging,
pubmed-meshheading:6608728-Animals,
pubmed-meshheading:6608728-Antibodies,
pubmed-meshheading:6608728-Antigen-Antibody Complex,
pubmed-meshheading:6608728-Female,
pubmed-meshheading:6608728-Fetus,
pubmed-meshheading:6608728-Ganglia, Spinal,
pubmed-meshheading:6608728-Nerve Growth Factors,
pubmed-meshheading:6608728-Pregnancy,
pubmed-meshheading:6608728-Radioimmunoassay,
pubmed-meshheading:6608728-Rats,
pubmed-meshheading:6608728-Rats, Inbred Strains,
pubmed-meshheading:6608728-Trigeminal Ganglion,
pubmed-meshheading:6608728-Trigeminal Nerve
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pubmed:year |
1984
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pubmed:articleTitle |
Biochemical and anatomical effects of antibodies against nerve growth factor on developing rat sensory ganglia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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