Linked Life Data

6607513

Source:http://linkedlifedata.com/resource/pubmed/id/6607513

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1984-2-29
pubmed:abstractText
The histocompatibility antigens B8 and DR3 are associated with several autoimmune diseases, and immune hyper-responsiveness has been believed to be one factor in the pathogenesis of these diseases. In the present study we compared the in vitro immunoglobulin production of healthy HLA-B8-positive individuals with that of HLA-B8-negative individuals. In HLA-B8-positive persons a higher number of pokeweed mitogen (PWM)-stimulated Ig-secreting cells was obtained. When the cells were stimulated with PWM in the presence of a physiological concentration of hydrocortisone (HC), the secretion of IgG was significantly higher in HLA-B8-positive individuals. This finding indicates that the PWM-stimulated IgG secretion in healthy HLA-B8-positive individuals is more sensitive for the enhancing action of HC.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0300-9475
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
551-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Increased immunoglobulin production in vitro in healthy HLA-B8-positive persons.
pubmed:publicationType
Journal Article, Comparative Study