Linked Life Data

6607025

Source:http://linkedlifedata.com/resource/pubmed/id/6607025

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1984-2-24
pubmed:abstractText
Cyclosporin (Cs)-binding sites on murine spleen lymphocytes and on Cs-sensitive (CsS) and Cs-resistant (CsR) cloned lymphoma lines were compared using a ditritiated derivative of cyclosporin C (d3H-CsC). All three types of lymphocytes displayed similar d3H-CsC-binding characteristics. There were no major differences in the d3H-CsC-binding sites in terms of their cell surface density (number per surface area), their affinity and their specificity (capacity to discriminate between different Cs forms). The presence of the presumably membranous Cs-binding site is therefore insufficient to confer susceptibility to Cs, and resistance can thus be obtained at a post-receptor level. With the CsS clone, there was a general correlation between the Cs-specific binding capacity and the Cs-specific biological activity inasmuch as Cs which were weakly or not at all cytostatic bound only very poorly to the d3H-CsC-binding site. Such a correlation could not be established in the case of a mixed spleen cell population; which implies that, in such a system, Cs processing might play a role in its activity. Binding to the receptor may be an early but only a permissive step in the mechanism of action of Cs.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-4910
pubmed:author
pubmed:issnType
Print
pubmed:volume
134D
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
207-22
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Cyclosporin-binding sites of murine sensitive and resistant lymphoid cell lines.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't