Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1984-1-27
pubmed:abstractText
Thymus development and T cell differentiation were studied in mouse chimaeras produced by aggregating pre-implantation embryos of thymus-deficient nude BALB/c (nu/nu) and wild-type C57BL/6 (+/+) mice and vice versa. Chimaeras showed mosaic distribution of skin and coat pigmentation, of hair follicles, of glucosephosphate isomerase within all tested organs and of lymphocytes expressing the different major transplantation antigens (H-2). When tested for their capacity to generate vaccinia virus-specific and self-H-2 specific cytotoxic T cells, all chimaeras of BALB/c (nu/nu) H-2d in equilibrium C57BL/6 (+/+) H-2b type generated T cells of one or both parental origins that were specific for virus and for self-H-2 of the +/+ (H-2b) type only. In contrast, some BALB/c (+/+) H-2d in equilibrium C57BL/6 (nu/nu) H-2b chimaeras generated vaccinia virus-specific cytotoxic T cells specific for either H-2d (+/+) type or for H-2b (nu/nu) type. These asymmetrical results can be interpreted to indicate the following: (i) The +/+ thymus part alone is functional, but because of asymmetrical cross-reactivities of anti-self-H-2 specificities, the observed T cell restriction phenotypes differ. (ii) Both nu/nu and +/+ thymus parts are functional but immune response defects may be exaggerated in such chimaeras producing unexpected non-responsiveness to vaccinia virus linked to H-2d in H-2b (+/+) in equilibrium H-2d (nu/nu).
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6605849-1010950, http://linkedlifedata.com/resource/pubmed/commentcorrection/6605849-1145127, http://linkedlifedata.com/resource/pubmed/commentcorrection/6605849-13775333, http://linkedlifedata.com/resource/pubmed/commentcorrection/6605849-310857, http://linkedlifedata.com/resource/pubmed/commentcorrection/6605849-386358, http://linkedlifedata.com/resource/pubmed/commentcorrection/6605849-4710784, http://linkedlifedata.com/resource/pubmed/commentcorrection/6605849-4823595, http://linkedlifedata.com/resource/pubmed/commentcorrection/6605849-5231615, http://linkedlifedata.com/resource/pubmed/commentcorrection/6605849-6184436, http://linkedlifedata.com/resource/pubmed/commentcorrection/6605849-6444970, http://linkedlifedata.com/resource/pubmed/commentcorrection/6605849-6940949, http://linkedlifedata.com/resource/pubmed/commentcorrection/6605849-6966312, http://linkedlifedata.com/resource/pubmed/commentcorrection/6605849-83702, http://linkedlifedata.com/resource/pubmed/commentcorrection/6605849-92183
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0261-4189
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1665-72
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Thymus differentiation and T-cell specificity in nu/nu +/+ mouse aggregation chimaeras.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't