Linked Life Data

6605666

Source:http://linkedlifedata.com/resource/pubmed/id/6605666

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1983-12-17
pubmed:abstractText
The influence of dantrolene, diazepam, pentobarbital and 4-aminopyridine on the depressant effect of active shortening during twitch and tetanus was investigated in isolated muscle fibres of the frog. These drugs are all presumed to alter the kinetics of the release and re-uptake of activator calcium during the excitation-contraction process. The shortening induced depression was calculated as the difference in redeveloped force after a small (control) and a larger (test) release step and was expressed in per cent of the control. The depressant effect in response to a given amount of shortening during twitch contraction as well as during the plateau of a tetanus was approximately doubled after addition of 10 microM dantrolene. In contrast, diazepam (150 microM) reduced the shortening effect during the twitch to about one tenth of the value obtained in ordinary Ringer solution, while the force depression by shortening during tetanic stimulation remained essentially unaltered. Pentobarbital (1.0 mM) reduced the shortening induced depression during the twitch by 95-100%. 4-aminopyridine (3.0 mM) completely abolished the depressant effect of shortening obtained during the twitch and approximately halved the shortening effect during tetanic contraction.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0001-6772
pubmed:author
pubmed:issnType
Print
pubmed:volume
118
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
317-27
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
The influence of dantrolene, diazepam, pentobarbital and 4-aminopyridine on shortening induced depression in isolated muscle fibres of the frog.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't