rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1983-12-17
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pubmed:abstractText |
The influence of the thymus and the possible requirement for surface immunoglobulin expression for the development of K and NK activity were assessed in rats. This species was chosen in preference to mice as they show good levels of K-cell activity. Studies were carried out in athymic (rnu/rnu) rats some of which were treated from birth with rabbit anti-rat IgM antibody to suppress B-cell development. The results indicate that normal levels of both K and NK activity develop in the spleens of 6-8-week-old athymic rats, which do not contain cells expressing surface membrane immunoglobulin. While K and NK cells show characteristics of the lymphoid lineage, neither the thymus nor surface membrane immunoglobulin expression appears to be required for development of normal levels of these cytolytic activities.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6605300-101595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6605300-299761,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6605300-304041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6605300-307688,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6605300-309905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6605300-311511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6605300-4137315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6605300-4197439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6605300-4541031,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6605300-4544247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6605300-4549140,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6605300-4617353,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6605300-52180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6605300-5452816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6605300-6123534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6605300-6156843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6605300-6166701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6605300-632589,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6605300-6446578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6605300-6453444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6605300-6788570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6605300-6788841,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6605300-6973348,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6605300-6976212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6605300-6976894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6605300-7003001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6605300-7057031,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6605300-712079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6605300-7307081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6605300-7365244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6605300-7408240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6605300-806020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6605300-81858
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
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pubmed:month |
Nov
|
pubmed:issn |
0019-2805
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:volume |
50
|
pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
327-34
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6605300-Animals,
pubmed-meshheading:6605300-Antibody-Dependent Cell Cytotoxicity,
pubmed-meshheading:6605300-B-Lymphocytes,
pubmed-meshheading:6605300-Cytotoxicity, Immunologic,
pubmed-meshheading:6605300-Germ-Free Life,
pubmed-meshheading:6605300-Immune Sera,
pubmed-meshheading:6605300-Immunosuppression,
pubmed-meshheading:6605300-Killer Cells, Natural,
pubmed-meshheading:6605300-Rats,
pubmed-meshheading:6605300-Rats, Mutant Strains,
pubmed-meshheading:6605300-Spleen,
pubmed-meshheading:6605300-Thymus Gland
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pubmed:year |
1983
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pubmed:articleTitle |
Antibody-dependent cellular cytotoxicity (K) and natural killing (NK) in B-suppressed germ-free nude rats.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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