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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
|
pubmed:dateCreated |
1978-8-14
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pubmed:abstractText |
The extraction of daunorubicin and doxorubicin and their hydroxyl metabolites daunorubicinol and doxorubicinol was studied using chloroform-1-pentanol (9:1) as the organic phase. Because of differences in acid dissociation constants, the pH for optimum extraction varied from 8.0 to 8.6 for the different compounds. Self-association in the aqueous phase significantly influenced the distribution ratio. Constants for the formation of dimers and tetramers in aqueous solutions were about 10(4.5) and 10(12), respectively.
|
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
|
pubmed:issn |
0022-3549
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
|
pubmed:pagination |
782-5
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:660455-Chemistry, Physical,
pubmed-meshheading:660455-Daunorubicin,
pubmed-meshheading:660455-Doxorubicin,
pubmed-meshheading:660455-Light,
pubmed-meshheading:660455-Models, Chemical,
pubmed-meshheading:660455-Physicochemical Phenomena,
pubmed-meshheading:660455-Solubility,
pubmed-meshheading:660455-Solutions,
pubmed-meshheading:660455-Spectrophotometry,
pubmed-meshheading:660455-Water
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pubmed:year |
1978
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pubmed:articleTitle |
Extraction of daunorubicin and doxorubicin and their hydroxyl metabolites: self-association in aqueous solution.
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pubmed:publicationType |
Journal Article
|