| pubmed-article:6604126 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6604126 | lifeskim:mentions | umls-concept:C0031272 | lld:lifeskim |
| pubmed-article:6604126 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:6604126 | lifeskim:mentions | umls-concept:C0596638 | lld:lifeskim |
| pubmed-article:6604126 | lifeskim:mentions | umls-concept:C0020835 | lld:lifeskim |
| pubmed-article:6604126 | lifeskim:mentions | umls-concept:C0003261 | lld:lifeskim |
| pubmed-article:6604126 | lifeskim:mentions | umls-concept:C2752630 | lld:lifeskim |
| pubmed-article:6604126 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:6604126 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:6604126 | lifeskim:mentions | umls-concept:C1998811 | lld:lifeskim |
| pubmed-article:6604126 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:6604126 | pubmed:dateCreated | 1983-10-8 | lld:pubmed |
| pubmed-article:6604126 | pubmed:abstractText | Our previous studies indicated that cloned T cells obtained from Peyer's patches (PP) (Lyt-1+, 2-, Ia+, and H-2K/D+) evoked immunoglobulin (Ig) class switching of PP B cells from sIgM to sIgA cells in vitro; however, these switch T cells could not in themselves provide optimal help for the differentiation of postswitch sIgA-bearing PP B cells to IgA-secreting cells. Thus, in the present report we described studies focused on mechanisms regulating terminal differentiation of the postswitch PP sIgA-bearing B cells. First, to explore the effect of T cell-derived B cell differentiation factor(s) (BCDF) and macrophage factor(s) (MF) on the terminal maturation of PP B cells, LPS-stimulated PP B cells were co-cultured for 7 d with cloned T cells in the presence or absence of the above factors. In the absence of PP cloned T cells the BCDF and MF had only a modest effect on IgA production, whereas in the presence of PP, but not spleen cloned T cells, IgA production was increased. Next, to investigate the effect of T cells derived from a gut-associated lymphoid tissue (GALT), mesenteric lymph nodes (MLN), as well as from spleen on terminal differentiation of postswitch sIgA PP B cells, LPS-driven PP B cells were precultured with the cloned T cells to induce a switch to sIgA, and subsequently cultured with MLN or spleen T cells or a Lyt-2+-depleted T cell subset in the presence of a T-dependent polyclonal mitogen, staphylococcal protein A. Alternatively, in the second culture period BCDF alone was added, instead of T cells and protein A. Here it was found that B cells pre-exposed to switch T cells from PP, but not spleen, were induced to produce greatly increased amounts of IgA in the presence of protein A and T cells or a Lyt-2+-depleted T cell subset as well as in the presence of BCDF alone. Furthermore, in the presence of BCDF alone many B cells expressed cytoplasmic IgA. These observations strongly support the view that the terminal differentiation of postswitch sIgA B cells is governed by helper T cells and macrophages, or factors derived from such cells. Such cells or factors do not affect preswitch B cells. | lld:pubmed |
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| pubmed-article:6604126 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:6604126 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6604126 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6604126 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:6604126 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:6604126 | pubmed:author | pubmed-author:StrobelMM | lld:pubmed |
| pubmed-article:6604126 | pubmed:author | pubmed-author:KawanishiHH | lld:pubmed |
| pubmed-article:6604126 | pubmed:author | pubmed-author:SaltzmanLL | lld:pubmed |
| pubmed-article:6604126 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6604126 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:6604126 | pubmed:volume | 158 | lld:pubmed |
| pubmed-article:6604126 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6604126 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6604126 | pubmed:pagination | 649-69 | lld:pubmed |
| pubmed-article:6604126 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6604126 | pubmed:year | 1983 | lld:pubmed |
| pubmed-article:6604126 | pubmed:articleTitle | Mechanisms regulating IgA class-specific immunoglobulin production in murine gut-associated lymphoid tissues. II. Terminal differentiation of postswitch sIgA-bearing Peyer's patch B cells. | lld:pubmed |
| pubmed-article:6604126 | pubmed:publicationType | Journal Article | lld:pubmed |
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