Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1983-9-9
pubmed:abstractText
The association of HLA-A,B,C, DR polymorphisms and of Bf and GLO with coeliac disease was analysed in 100 Italian children. Primary involvement of HLA-DR3 and DR7 is apparent, while specificities of nearby loci are probably associated secondarily, because of linkage disequilibrium. Direct assessment of D/DR genotype through family studies and mixed lymphocyte cultures led to the recognition of two high risk genotypes DR3/3 and DR3/7, and of two lower risk genotypes DR3/X and DR7/X. The different weight of the HLA-dependent genetic factors is to some extent correlated with the clinical and immunological parameters, suggesting that the low-risk genotypes induce a milder expression of coeliac disease. Furthermore, other genetic factors, such as sex, appear to contribute to the penetrance of the disease, especially in the case of DR3/X and DR7/X.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6603391-13808015, http://linkedlifedata.com/resource/pubmed/commentcorrection/6603391-14242522, http://linkedlifedata.com/resource/pubmed/commentcorrection/6603391-307512, http://linkedlifedata.com/resource/pubmed/commentcorrection/6603391-391038, http://linkedlifedata.com/resource/pubmed/commentcorrection/6603391-4114064, http://linkedlifedata.com/resource/pubmed/commentcorrection/6603391-4161976, http://linkedlifedata.com/resource/pubmed/commentcorrection/6603391-4204534, http://linkedlifedata.com/resource/pubmed/commentcorrection/6603391-4956917, http://linkedlifedata.com/resource/pubmed/commentcorrection/6603391-5024049, http://linkedlifedata.com/resource/pubmed/commentcorrection/6603391-5157137, http://linkedlifedata.com/resource/pubmed/commentcorrection/6603391-535724, http://linkedlifedata.com/resource/pubmed/commentcorrection/6603391-5461629, http://linkedlifedata.com/resource/pubmed/commentcorrection/6603391-55781, http://linkedlifedata.com/resource/pubmed/commentcorrection/6603391-6103441, http://linkedlifedata.com/resource/pubmed/commentcorrection/6603391-6771551, http://linkedlifedata.com/resource/pubmed/commentcorrection/6603391-6946724, http://linkedlifedata.com/resource/pubmed/commentcorrection/6603391-6947507, http://linkedlifedata.com/resource/pubmed/commentcorrection/6603391-6977217, http://linkedlifedata.com/resource/pubmed/commentcorrection/6603391-7034532, http://linkedlifedata.com/resource/pubmed/commentcorrection/6603391-7282774, http://linkedlifedata.com/resource/pubmed/commentcorrection/6603391-734750, http://linkedlifedata.com/resource/pubmed/commentcorrection/6603391-7400313, http://linkedlifedata.com/resource/pubmed/commentcorrection/6603391-87027, http://linkedlifedata.com/resource/pubmed/commentcorrection/6603391-94703
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0017-5749
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
706-12
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
HLA-DR3 and DR7 in coeliac disease: immunogenetic and clinical aspects.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't