pubmed-article:6602340 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:6602340 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
pubmed-article:6602340 | lifeskim:mentions | umls-concept:C0330390 | lld:lifeskim |
pubmed-article:6602340 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
pubmed-article:6602340 | lifeskim:mentions | umls-concept:C0032043 | lld:lifeskim |
pubmed-article:6602340 | lifeskim:mentions | umls-concept:C0040691 | lld:lifeskim |
pubmed-article:6602340 | lifeskim:mentions | umls-concept:C0205265 | lld:lifeskim |
pubmed-article:6602340 | lifeskim:mentions | umls-concept:C1998793 | lld:lifeskim |
pubmed-article:6602340 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
pubmed-article:6602340 | lifeskim:mentions | umls-concept:C1555582 | lld:lifeskim |
pubmed-article:6602340 | pubmed:issue | 12 | lld:pubmed |
pubmed-article:6602340 | pubmed:dateCreated | 1983-7-15 | lld:pubmed |
pubmed-article:6602340 | pubmed:abstractText | A polypeptide transforming growth factor (TGF) that induces anchorage-dependent rat kidney fibroblasts to grow in soft agar has been isolated from human placenta and purified to homogeneity. This polypeptide is classified as a type beta TGF because it does not compete with epidermal growth factor (EGF) for membrane receptor sites but does require EGF for induction of anchorage-independent growth of indicator cells. Purification of this peptide was achieved by acid/ethanol extraction of the placenta, followed by gel filtration, cation exchange, and HPLC of the acid-soluble proteins. Homogeneity of the TGF-beta from the final column was shown by its constant specific activity and amino acid composition across the peak of soft agar colony-forming activity and by its migration as a single band at Mr 23,000-25,000 on NaDodSO4/polyacrylamide gel electrophoresis. Under reducing conditions, the protein migrated on a gel as a single band at Mr 13,000. The purified placental TGF-beta caused half-maximal growth stimulation of indicator cells in soft agar at 64-72 pg/ml (3 pM) in the presence of EGF at 2 ng/ml (0.34 nM). | lld:pubmed |
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pubmed-article:6602340 | pubmed:language | eng | lld:pubmed |
pubmed-article:6602340 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6602340 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:6602340 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:6602340 | pubmed:month | Jun | lld:pubmed |
pubmed-article:6602340 | pubmed:issn | 0027-8424 | lld:pubmed |
pubmed-article:6602340 | pubmed:author | pubmed-author:MeyersC ACA | lld:pubmed |
pubmed-article:6602340 | pubmed:author | pubmed-author:SmithD MDM | lld:pubmed |
pubmed-article:6602340 | pubmed:author | pubmed-author:SpornM BMB | lld:pubmed |
pubmed-article:6602340 | pubmed:author | pubmed-author:FrolikC ACA | lld:pubmed |
pubmed-article:6602340 | pubmed:author | pubmed-author:GABRMM | lld:pubmed |
pubmed-article:6602340 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:6602340 | pubmed:volume | 80 | lld:pubmed |
pubmed-article:6602340 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:6602340 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:6602340 | pubmed:pagination | 3676-80 | lld:pubmed |
pubmed-article:6602340 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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pubmed-article:6602340 | pubmed:year | 1983 | lld:pubmed |
pubmed-article:6602340 | pubmed:articleTitle | Purification and initial characterization of a type beta transforming growth factor from human placenta. | lld:pubmed |
pubmed-article:6602340 | pubmed:publicationType | Journal Article | lld:pubmed |
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