Linked Life Data

6602182

Source:http://linkedlifedata.com/resource/pubmed/id/6602182

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1983-7-8
pubmed:abstractText
Lipopolysaccharides (LPS) of homogeneous monomeric composition were prepared by gel filtration chromatography of detergent-dissociated LPS from the smooth strain of E. coli 055:B5. Splenocyte mitogenic activity of reassociated column fractions and fraction pools is markedly dependent upon the ratio of O-antigen polysaccharide to lipid A. The activity of the homogeneous LPS in eliciting spleen cell responses varied by approximately three orders of magnitude. One of the fraction pools rich in lipid A (which contains only a trace of O-antigen polysaccharide) induces a spleen cell proliferative response in C3H/HeJ "LPS-nonresponder" spleen cells. This mitogenic activity is not present in either unfractionated LPS or O-antigen-rich fractions. These latter findings indicate LPS macromolecular aggregates of the appropriate physicochemical structure have the capacity to elicit C3H/HeJ spleen cell proliferative responses.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:volume
130
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2804-8
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Conversion of lipopolysaccharides to molecular aggregates with reduced subunit heterogeneity: demonstration of LPS-responsiveness in "endotoxin-unresponsive" C3H/HeJ splenocytes.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.