Linked Life Data

6602092

Source:http://linkedlifedata.com/resource/pubmed/id/6602092

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1983-7-8
pubmed:abstractText
Mononuclear cell accumulation in rat skin sites, over a 24 h period following intradermal injections of concanavalin A (Con A) and carrageenan, was quantitated using an isotopic technique. Cyclosporin A (CS-A) inhibited the accumulation of [51Cr]-labelled blood mononuclear cells into cutaneous reactions to Con A but not carrageenan reactions in the same animals. Conversely, indomethacin or cobra venom factor inhibited cell accumulation into carrageenan-induced lesion, whilst leaving infiltration into Con A reactions unimpaired. Since CS-A did not show a general anti-inflammatory effect, it is suggested that this compound reduces cell accumulation by inhibiting the local release of lymphokines in vivo.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0165-2478
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
69-72
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Cyclosporin A--a pre-recruitment action in the cutaneous response?
pubmed:publicationType
Journal Article, Comparative Study