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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1983-4-15
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pubmed:abstractText |
We have previously shown that lymphoblasts alloactivated in vitro acquire the capacity of stimulating the autologous mixed lymphocyte response. This response is anti-idiotypic in nature because lymphocytes so primed display accelerated memory responses only when restimulated by autologous lymphoblasts that have been alloactivated against the same HLA-DR antigen. Based on this observation we have postulated that the absence of HLA antibodies in alloimmunized human subjects may be due to the development of autoantibodies that react with the anti-HLA receptors expressed by primed lymphocytes or by anti-HLA antibodies or both. This hypothesis has been confirmed in the present investigations which show that sera from parous women react with autologous T lymphoblasts primed in 5-day mixed lymphocyte culture against their husband-i.e., with lymphoblasts expressing receptors for the immunizing donor. Anti-HLA receptors expressed by T and B lymphocytes seem to share serologic determinants because sera that bind to autologous alloactivated lymphoblasts are also capable of inhibiting the anti-HLA activity of autologous and homologous sera. Auto-anti-idiotypic antibodies inhibit the autologous mixed lymphocyte response to autologous alloactivated lymphoblasts, a phenomenon whose in vivo correlate may reside in autoinhibition of anti-HLA antibody formation and of allograft immunity. Because auto-anti-idiotypic antibodies were found in sera from all parous women tested, the hypothesis that nonresponsiveness to alloantigens exists as a state per se is not likely. The passive transfer of antireceptor (idiotype) immunity by use of antibodies from pregnant women's sera may provide a powerful tool for specific suppression of allograft rejection.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600840-10649,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600840-331569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600840-33224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600840-408091,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600840-4270240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600840-6161968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600840-6173456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600840-6174671,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600840-6177823,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600840-6808075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600840-6946986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600840-69518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600840-6968909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600840-7051480
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
80
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
830-4
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6600840-Antibodies, Anti-Idiotypic,
pubmed-meshheading:6600840-Female,
pubmed-meshheading:6600840-HLA Antigens,
pubmed-meshheading:6600840-HLA-DR Antigens,
pubmed-meshheading:6600840-Histocompatibility Antigens Class II,
pubmed-meshheading:6600840-Humans,
pubmed-meshheading:6600840-Immunoglobulin Idiotypes,
pubmed-meshheading:6600840-Parity,
pubmed-meshheading:6600840-Pregnancy,
pubmed-meshheading:6600840-Receptors, Antigen, T-Cell
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pubmed:year |
1983
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pubmed:articleTitle |
Anti-idiotypic antibodies to anti-HLA receptors induced by pregnancy.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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