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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1983-3-24
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pubmed:abstractText |
The observation that anti-immunoglobulin antibodies and T cell-replacing factor (TRF) have a synergistic effect on the stimulation of B lymphocytes to differentiate into antibody-secreting cells suggested to us the possibility that the crosslinking of B-cell surface immunoglobulin by antigen or anti-immunoglobulin antibody might induce the expression of a B-cell receptor for TRF. In order to test this possibility we studied whether spleen cells from mice injected with 400-800 micrograms of anti-IgD antibody 1-3 days before sacrifice had an enhanced capacity to adsorb TRF activity from a partially purified culture supernatant of concanavalin A-stimulated mouse spleen cells. We found that spleen cells from euthymic or congenitally athymic mice injected 24-30 hr prior to sacrifice with either affinity-purified goat anti-mouse IgD antibody or a monoclonal allospecific anti-IgD antibody had greater than 100 times the TRF adsorptive capacity of spleen cells from control mice. In contrast, spleen cells from anti-IgD treated DBA/2Ha mice, which have been shown to have an immune defect associated with the lack of a TRF receptor, were unable to adsorb TRF activity from concanavalin A-stimulated helper supernatants. This suggests that the crosslinking of B-cell surface immunoglobulin may induce B lymphocytes to express a receptor or receptors for TRF and thus enhance B-cell responsiveness to this helper factor.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600516-1081652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600516-1094630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600516-307581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600516-379222,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600516-393521,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600516-4163709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600516-5653817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600516-5762048,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600516-6170682,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600516-6177772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600516-6177773,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600516-6768803,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600516-6776225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600516-6778922,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600516-6790620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600516-6965971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600516-6965972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600516-6967895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600516-6969778,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600516-6970212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600516-6975305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600516-7019041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600516-7021396
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
80
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
293-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6600516-Animals,
pubmed-meshheading:6600516-Antibodies, Anti-Idiotypic,
pubmed-meshheading:6600516-B-Lymphocytes,
pubmed-meshheading:6600516-Immunoglobulin D,
pubmed-meshheading:6600516-Interleukin-5,
pubmed-meshheading:6600516-Lymphokines,
pubmed-meshheading:6600516-Mice,
pubmed-meshheading:6600516-Receptors, Antigen, B-Cell,
pubmed-meshheading:6600516-Receptors, Immunologic
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pubmed:year |
1983
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pubmed:articleTitle |
Induction of a B-lymphocyte receptor for a T cell-replacing factor by the crosslinking of surface IgD.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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