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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1983-3-24
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pubmed:abstractText |
Lymph node and spleen cells of the autoimmune MRL/Mp-lpr/lpr mouse strain spontaneously produce (in the absence of mitogenic stimulation) a factor(s) that induces B cell differentiation. This factor is not produced by the congenic MRL/n mouse strain that lacks the lpr gene or by normal mouse strains. However, lymphoid cells of the B6-lpr/lpr (B6/1) strain also produce a B cell differentiation factor. Although the factor acts on resting B cells, its effect is greatly magnified by activating the B cells with anti-mu or lipopolysaccharide. MRL/l mice begin producing the factor as early as 1 mo of age but levels increase with age and appearance of lymphoproliferation. Cell depletion studies reveal that this factor is produced by T cells of the Lyt-1+2-phenotype. Because of its association with the lpr/lpr genotype, we term this B cell differentiation factor L-BCDF. Functional analysis of L-BCDF reveals that it acts regardless of cell density in culture and in the absence of interleukin 2 (IL-2). In fact, the increase in the production of L-BCDF by MRL/1 T cells with aging occurs concomitantly with a marked decrease in their ability to produce IL-2. No T cell replacing factor activity or B cell growth factor-like activity can be detected in MRL/l-derived supernatants. L-BCDF induces both IgM and IgG synthesis in lipopolysaccharide-activated B cells; however, it has a greater effect on IgG secretion. In particular, the production of IgG1, IgG2a, and IgG2b are markedly enhanced in the presence of L-BCDF. The spontaneous production of L-BCDF by T cells of SLE mice of lpr/lpr genotype suggests an association of this factor with autoimmunity.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600490-1094630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600490-307029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600490-309911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600490-311816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600490-315987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600490-351618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600490-376732,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600490-4610054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600490-6165672,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600490-6176399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600490-6444324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600490-6456321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600490-65435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600490-6806371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600490-6809819,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600490-6965972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600490-6967509,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600490-6967895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600490-6969857,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600490-6972998,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600490-6975325,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600490-6975351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600490-7021394,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600490-7038025,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600490-7042542,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600490-7042545,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600490-7044952,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600490-7241048,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600490-7391583,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600490-762500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600490-89034
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
157
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
730-42
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6600490-Aging,
pubmed-meshheading:6600490-Animals,
pubmed-meshheading:6600490-Autoimmune Diseases,
pubmed-meshheading:6600490-B-Lymphocytes,
pubmed-meshheading:6600490-Concanavalin A,
pubmed-meshheading:6600490-Female,
pubmed-meshheading:6600490-Genotype,
pubmed-meshheading:6600490-Growth Substances,
pubmed-meshheading:6600490-Immunoglobulin G,
pubmed-meshheading:6600490-Immunoglobulin M,
pubmed-meshheading:6600490-Interleukin-2,
pubmed-meshheading:6600490-Interleukin-4,
pubmed-meshheading:6600490-Lupus Erythematosus, Systemic,
pubmed-meshheading:6600490-Lymphocyte Activation,
pubmed-meshheading:6600490-Lymphokines,
pubmed-meshheading:6600490-Mice,
pubmed-meshheading:6600490-Mice, Inbred BALB C,
pubmed-meshheading:6600490-Mice, Inbred C3H,
pubmed-meshheading:6600490-Mice, Inbred C57BL,
pubmed-meshheading:6600490-Mice, Mutant Strains,
pubmed-meshheading:6600490-T-Lymphocytes
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pubmed:year |
1983
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pubmed:articleTitle |
Identification of a B cell differentiation factor(s) spontaneously produced by proliferating T cells in murine lupus strains of the lpr/lpr genotype.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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