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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1983-3-24
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pubmed:abstractText |
Staphylococcal cell wall products have been widely examined as probes for dissection of in vitro human immune responses. Mitogenic and polyclonal B-cell-activating properties have been attributed to intact cell walls or the protein A constituent thereof. We now report that staphylococcal peptidoglycan (PG), the major cell wall constituent, is not only a potent mitogen but also a polyclonal B-cell activator for human peripheral blood mononuclear cells (PBM). PG-induced proliferative responses of human PBM were comparable to that observed in pokeweed mitogen-stimulated cultures. As was true for pokeweed mitogen, PG-induced proliferation required the presence of T-cell help. Cultures of human PBM with PG also resulted in B-cell differentiation as reflected by an increase in numbers of immunoglobulin-secreting cells in stimulated cultures. In contrast to the proliferative response, PG-induced B-cell differentiation was relatively T-cell independent. This point became apparent when B-cell fractions were partially depleted of excessive numbers of monocytes before culture. Also, B-cell proliferation did not appear to be a major prerequisite for PG-induced B-cell differentiation responses. These data indicate that PG is a potent T-cell-dependent mitogen and relatively T-cell-independent polyclonal B-cell activator of human lymphocytes.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600446-1086776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600446-1087313,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600446-1095681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600446-193041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600446-221572,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600446-300089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600446-304871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600446-308522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600446-309629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600446-311814,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600446-312859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600446-313370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600446-31677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600446-363939,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600446-368235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600446-382482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600446-386360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600446-387423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600446-389443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600446-5706694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600446-6256442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600446-6444316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600446-6965954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600446-6966649,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600446-6967091,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600446-6968784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600446-6971331,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600446-6972434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600446-7429652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600446-794413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600446-807626
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
290-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1983
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pubmed:articleTitle |
Staphylococcal peptidoglycan: T-cell-dependent mitogen and relatively T-cell-independent polyclonal B-cell activator of human lymphocytes.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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