Linked Life Data

6599498

Source:http://linkedlifedata.com/resource/pubmed/id/6599498

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1986-2-18
pubmed:abstractText
Spontaneously hypertensive (SHR) and Wistar-Kyoto rats (WKY) were compared with regard to the interaction between cortico-hypothalamic alerting responses and the baroreflex influences on neurogenic cardiovascular control. Baroreceptor sensitivity was assessed as heart rate (HR) and renal sympathetic nerve activity (RSNA) reduction per mmHg mean arterial pressure (MAP) increase by phenylephrine infusion. Response to 'mental stress' was studied. Addition of 'mental stress' during baroreceptor activation (30 mmHg MAP increase) was also performed. RSNA was higher in SHR than in WKY during rest and increased more during stress. Baroreflex sensitivity was reduced in SHR compared with WKY concerning HR (0.44 +/- 0.06 versus 0.78 +/- 0.08%/mmHg). Percentage RSNA reduction was similar, while RSNA reduction appeared greater in SHR in comparison with WKY (0.10 +/- 0.02 and 0.06 +/- 0.01 microV/mmHg, P less than 0.12). During baroreflex activation 'mental stress' increased both HR (+24 +/- 7%) and RSNA (+114 +/- 21%) in SHR with almost no changes in WKY. The results suggest an increased cortico-hypothalamic activity in SHR, which is clearly augmented during 'mental stress' and readily overcomes baroreflex inhibitory influences on sympathetic activity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0952-1178
pubmed:author
pubmed:issnType
Print
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
68-70
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Interaction between mental stress and baroreceptor control of heart rate and sympathetic activity in conscious spontaneously hypertensive (SHR) and normotensive (WKY) rats.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't