Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1978-9-1
pubmed:abstractText
The effect of 8 mg/kg of indomethacin on uterine blood flow, prostaglandin production, and intraamniotic fluid pressure was examined in late pregnant dogs. Uterine blood flow was measured with 15 mum radiolabeled microspheres. Because we found that a significant percentage of the microspheres shunted through the placental circulation into the lungs, we calculated placental blood flow by adding the shunted microspheres through the placenta to the nonshunted microspheres in the placenta. Total uterine blood flow significantly increased from 271+/-69 ml/min during control period to 371+/-72 ml/min (P < 0.01) 30 min after indomethacin. This increase was attributable to the change in blood flow to the placental circulation (222+/-58 to 325+/-63 ml/min; P < 0.01). Associated with these hemodynamic changes we found an almost complete suppression of uterine prostaglandin E(2) production (1,654+/-305 to 51+/-25 pg/ml; P < 0.01) as measured by gas chromatography-mass spectrometry. In addition, we found that indomethacin treatment resulted in uterine relaxation as measured by intraamniotic fluid pressure changes (11.2+/-1.3 mm Hg to 8.5+/-1.2 mm Hg; P < 0.001). We conclude that indomethacin causes an increase in placental blood flow without any change in flow to the rest of the uterus, and that this dose of the drug inhibits greater than 95% of uterine prostaglandin production. In addition, indomethacin is responsible for uterine relaxation. The increase in placental blood flow after indomethacin is probably a result of uterine relaxation, which is secondary to prostaglandin synthesis inhibition.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/659627-1053518, http://linkedlifedata.com/resource/pubmed/commentcorrection/659627-1096612, http://linkedlifedata.com/resource/pubmed/commentcorrection/659627-1109179, http://linkedlifedata.com/resource/pubmed/commentcorrection/659627-1197785, http://linkedlifedata.com/resource/pubmed/commentcorrection/659627-14208157, http://linkedlifedata.com/resource/pubmed/commentcorrection/659627-320630, http://linkedlifedata.com/resource/pubmed/commentcorrection/659627-4127544, http://linkedlifedata.com/resource/pubmed/commentcorrection/659627-4203899, http://linkedlifedata.com/resource/pubmed/commentcorrection/659627-4239830, http://linkedlifedata.com/resource/pubmed/commentcorrection/659627-4437814, http://linkedlifedata.com/resource/pubmed/commentcorrection/659627-4453621, http://linkedlifedata.com/resource/pubmed/commentcorrection/659627-4570635, http://linkedlifedata.com/resource/pubmed/commentcorrection/659627-4570636, http://linkedlifedata.com/resource/pubmed/commentcorrection/659627-4660072, http://linkedlifedata.com/resource/pubmed/commentcorrection/659627-4745182, http://linkedlifedata.com/resource/pubmed/commentcorrection/659627-4822205, http://linkedlifedata.com/resource/pubmed/commentcorrection/659627-4823627, http://linkedlifedata.com/resource/pubmed/commentcorrection/659627-4914185, http://linkedlifedata.com/resource/pubmed/commentcorrection/659627-4952708, http://linkedlifedata.com/resource/pubmed/commentcorrection/659627-5041468, http://linkedlifedata.com/resource/pubmed/commentcorrection/659627-5649820, http://linkedlifedata.com/resource/pubmed/commentcorrection/659627-5784297, http://linkedlifedata.com/resource/pubmed/commentcorrection/659627-807955, http://linkedlifedata.com/resource/pubmed/commentcorrection/659627-826873, http://linkedlifedata.com/resource/pubmed/commentcorrection/659627-842676, http://linkedlifedata.com/resource/pubmed/commentcorrection/659627-857274, http://linkedlifedata.com/resource/pubmed/commentcorrection/659627-944622, http://linkedlifedata.com/resource/pubmed/commentcorrection/659627-959575, http://linkedlifedata.com/resource/pubmed/commentcorrection/659627-970455
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0021-9738
pubmed:author
pubmed:issnType
Print
pubmed:volume
62
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
14-9
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1978
pubmed:articleTitle
Indomethacin is a placental vasodilator in the dog. The effect of prostaglandin inhibition.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.