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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
1985-1-31
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pubmed:abstractText |
Cisplatinum given intravenously (i.v.), hydroxyurea given orally (os), procarbazine (os) and L-asparaginase (i.v.), on a decreasing scale, produce significant (p less than 0.01) adrenocortical activation over 4-h period at a single dose per kg 10 times higher than those employed in human therapy. Only hydroxyurea retained this activity after a 5-day treatment both in normal and Walker carcinosarcoma-bearing rats. Adrenocortical activation depends on the presence of pituitary ACTH both after single or repeated treatments.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0171-9750
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
98-102
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6596030-Adrenal Cortex,
pubmed-meshheading:6596030-Animals,
pubmed-meshheading:6596030-Antineoplastic Agents,
pubmed-meshheading:6596030-Carcinoma 256, Walker,
pubmed-meshheading:6596030-Corticosterone,
pubmed-meshheading:6596030-Hypophysectomy,
pubmed-meshheading:6596030-Male,
pubmed-meshheading:6596030-Pituitary-Adrenal System,
pubmed-meshheading:6596030-Rats,
pubmed-meshheading:6596030-Rats, Inbred Strains
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pubmed:year |
1984
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pubmed:articleTitle |
Tolerance to pituitary-adrenal axis activation by anticancer drugs in normal and tumour-bearing rats.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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