Linked Life Data

6595484

Source:http://linkedlifedata.com/resource/pubmed/id/6595484

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1985-2-11
pubmed:abstractText
We have examined the expression of three cellular oncogenes (c-Ki-ras, c-Ha-ras and c-myc) in different stages of murine erythroleukemias induced in ICFW mice by Friend viruses (F-MuLV and SFFV) in comparison to normal mice spleens and bone marrows, including erythropoietically-stimulated spleens from phenylhydrazine-treated mice. There is no evidence of c-Ki-ras RNA expression in any of the tissues tested. c-Ha-ras RNA was found at similar levels in erythroleukemic cells and normal erythroid cells. In contrast, increased levels of normal 2.3 Kb and short 1.8 Kb c-myc RNA transcripts were detected in both early preleukemic and late leukemic phases of the diseases, as compared to normal erythroid cells. Apparently, neither myc gene amplification nor myc gene rearrangement was observed in erythroleukemias. Our results suggest a possible involvement of c-myc gene either in erythroid cell differentiation or in an early proliferation step of the erythroleukemic process.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0145-2126
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
975-84
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Expression of c-ras and c-myc oncogenes in murine erythroleukemias induced by Friend viruses.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't