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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
|
pubmed:dateCreated |
1978-8-14
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pubmed:abstractText |
A soil isolate of Actinoplanes that produces the chemically unrelated new antibiotics teichomycins A1 and A2 has been proposed as a new species named Actinoplanes teichomyceticus nov. sp. (ATCC 31121). Studies of medium and fermentation conditions indicated that the highest antibiotic titers, ca 900 u/ml, are obtained in a medium containing 1% (w/v) glucose, 1% cotton seed meal, 1% malt extract, and 0.4% yeast extract. Both teichomycin A1 and teichomycin A2 are highly active against gram-positive bacteria. Teichomycin A1 shows some activity against gram-negative bacteria. Both antibiotics cured mice experimentally infected with sensitive bacteria and showed low acute toxicity. Of the two antibiotics teichomycin A2 is the more active.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
0021-8820
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
|
pubmed:pagination |
276-83
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:659325-Actinomycetales,
pubmed-meshheading:659325-Animals,
pubmed-meshheading:659325-Anti-Bacterial Agents,
pubmed-meshheading:659325-Fermentation,
pubmed-meshheading:659325-Lethal Dose 50,
pubmed-meshheading:659325-Mice,
pubmed-meshheading:659325-Microbial Sensitivity Tests,
pubmed-meshheading:659325-Time Factors
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pubmed:year |
1978
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pubmed:articleTitle |
Teichomycins, new antibiotics from Actinoplanes teichomyceticus Nov. Sp. I. Description of the producer strain, fermentation studies and biological properties.
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pubmed:publicationType |
Journal Article
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