Linked Life Data

6593116

Source:http://linkedlifedata.com/resource/pubmed/id/6593116

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1984-11-28
pubmed:abstractText
The calcium content of pleiotropic drug-resistant tumor cells was estimated and compared with that of the parent tumor lines. P388 leukemia cells resistant to vincristine and Adriamycin contained more calcium (1.5- to 1.8-fold) in the cells and on the cell surface than the parent P388 cells. Similar results were obtained with human K562 myelogenous leukemia cells resistant to vincristine and also with Chinese hamster ovary cells resistant to colchicine. However, the calcium content of P388 cells resistant to 5-fluorouracil was almost the same as that of the parent P388 cells. The calmodulin content of pleiotropic resistant tumor lines and a 5-fluorouracil-resistant tumor line was almost the same as that of the corresponding parent lines. The isolated plasma membrane of K562 cells resistant to vincristine contained approximately 1.5-fold higher calcium than the parent cells. These results indicate that the higher cellular calcium content might be a characteristic phenotype of pleiotropic resistant tumor lines.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0008-5472
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5095-9
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
High calcium content of pleiotropic drug-resistant P388 and K562 leukemia and Chinese hamster ovary cells.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't