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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
1984-11-5
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pubmed:abstractText |
The influence of configuration at C-20 on rotation about the 17(20)-bond in steroids and euphoids was examined by x-ray crystallographic studies of the C-20 epimers euphol and tirucallol. The H atom on C-20 was in back next to C-18 in the crystal structures of both of the compounds, and C-22 was found to be cis-oriented ("left-handed") to C-13 in euphol and trans-oriented to it ("right-handed") in tirucallol. The results, which are consistent with the known left-handed crystal structure of 24(25)-dihydroeuphol and right-handed crystal structure of cholesterol and other natural sterols, lend further credence to the earlier suggestion that rotational isomerism at the 17(20)-bond can arise in C-20 epimers and that there is preference for an arrangement with the 20-H atom adjacent to C-18.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6592593-1133610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6592593-16661523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6592593-355252,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6592593-416029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6592593-4826675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6592593-6289321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6592593-6340686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6592593-6793681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6592593-7421432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6592593-830681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6592593-985641
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5896-900
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pubmed:dateRevised |
2010-9-10
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pubmed:meshHeading |
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pubmed:year |
1984
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pubmed:articleTitle |
Rotational isomerism about the 17(20)-bond of steroids and euphoids as shown by the crystal structures of euphol and tirucallol.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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