Linked Life Data

6589336

Source:http://linkedlifedata.com/resource/pubmed/id/6589336

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1984-9-13
pubmed:abstractText
Macrophages, derived from human monocytes by in vitro culture, released a growth factor for rabbit lung fibroblasts. The release of growth factor was increased following stimulation with both soluble (lipopolysaccharide and phorbol myristate acetate) and particulate (opsonized zymosan) substances. Production of the growth factor activity was dependent on the length of time the monocytes were in culture, the presence of serum during the period of monocyte maturation, and macrophage protein synthesis. The inability of serum-deprived monocytes to produce growth factor could be reversed by adding back serum. Eicosatetraynoic acid and dexamethasone but not indomethacin inhibited the production of growth factor suggesting that arachidonic acid metabolites other than prostaglandins may regulate growth factor production.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0741-5400
pubmed:author
pubmed:issnType
Print
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
143-59
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Production of growth factor activity for fibroblasts by human monocyte-derived macrophages.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't