Linked Life Data

6588253

Source:http://linkedlifedata.com/resource/pubmed/id/6588253

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1984-8-15
pubmed:abstractText
Sympathetic nervous activity, which we defined as the relative rate of appearance of norepinephrine (NE) in plasma, was investigated in normal men (control) and uremic patients with two-step steady-state cold NE infusions. Both basal venous NE and the NE metabolic clearance rate (CNE, calculated from the infusion rate and the steady-state increment in venous NE) were higher in patients than in controls. The calculated appearance rate of NE in venous plasma (CNE X basal NE) was much higher in the patients, suggesting increased NE release and therefore sympathetic nervous hyperactivity in these patients. Of interest was the fall in both CNE and NE appearance rate at the higher infusion rate in controls, but not patients. These data suggest that circulating NE may normally suppress sympathetic nervous activity, but that this negative feedback mechanism is impaired in uremia.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0098-6577
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S221-3
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Abnormal norepinephrine release in uremia.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.