Linked Life Data

6585178

Source:http://linkedlifedata.com/resource/pubmed/id/6585178

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1984-5-23
pubmed:abstractText
The antitumor compound adriamycin was found to induce differentiation-associated properties in human erythroleukemia K 562 cells. Studies on the relationship between drug concentration and the appearance of hemoglobin demonstrated that the more the rate of cell division was reduced during the 4 days of exposure, the higher was the accumulation of hemoglobin per cell. Considering the variation in the intracellular protein content during the response, it appears that adriamycin (40 nM) stimulated the synthesis of both hemoglobin and non-hemoglobin proteins while hemin, a well-known erythroid inducer, specifically increased hemoglobin synthesis. In addition, the lack of cell growth was associated with a recruitment of benzidine-positive cells. In contrast to hemin, adriamycin did not modify the electrophoretic pattern found in untreated cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0250-7005
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
47-51
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Induction of hemoglobin synthesis in human leukemic K 562 cells by adriamycin.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't