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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1984-4-12
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pubmed:abstractText |
Formation of a developmentally arrested dispersal stage called the dauer larva is enhanced by a Caenorhabditis-specific pheromone and is inhibited by increasing amounts of food. Pheromone-induced dauer larva formation of three tested wild-type strains is temperature-dependent, so that an increased percentage of the population forms dauer larvae at 25 degrees C compared to lower temperatures. Dauer-defective mutants fail to respond to added pheromone, and some behavioral mutants affected in thermotaxis or egg-laying also exhibit abnormal responses. Temperature-sensitive (ts) dauer-constitutive mutants form dauer larvae at a restrictive temperature regardless of environmental stimuli. At the permissive temperature (17.5 degrees C), alleles of six out of seven dauer-constitutive genes tested overrespond to the dauer-inducing pheromone. All known mutations in daf-4 (eight alleles) and daf-7 (five alleles) produce a ts dauer-constitutive phenotype. One daf-4 and one daf-7 allele are suppressed by the amber nonsense suppressor, sup-7(st5). At least these two dauer-constitutive mutations are likely to cause production of nonfunctional rather than ts gene products. These mutations appear to indirectly result in a ts phenotype by enhancing the expression of a wild-type ts developmental process.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583682-1060088,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583682-11813735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583682-1183723,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583682-292825,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583682-355261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583682-4366476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583682-446897,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583682-4858229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583682-5479624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583682-580424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583682-6304721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583682-6571695,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583682-6643716,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583682-6896933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583682-7014288,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583682-7121584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583682-7219552,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583682-7240452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583682-7250492,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583682-7250500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583682-7274656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583682-7371984,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583682-7380089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583682-943345
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
819-23
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1984
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pubmed:articleTitle |
A pheromone-induced developmental switch in Caenorhabditis elegans: Temperature-sensitive mutants reveal a wild-type temperature-dependent process.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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