Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1984-4-12
pubmed:abstractText
Nondividing (arrested) populations of primary human fibroblasts from normal individuals exposed to an initial dose (1.5 or 3 J X m-2) of far-UV (254 nm) radiation and then incubated in medium containing low (0.5%) serum develop enhanced resistance to inactivation of cloning efficiency by a second (challenge) dose of UV. The resistance develops within 2-4 days, after which there is a decline. Resistance develops to a higher degree and more rapidly (1-2 days) in cells derived from patients with the variant form of xeroderma pigmentosum. Excision-deficient cells from xeroderma pigmentosum complementation group A individuals also develop UV resistance after a lower (0.2 J X m-2) exposure to UV. Enhanced UV resistance does not develop in UV-irradiated cell populations incubated with the protein synthesis inhibitor cycloheximide (5 microM). These observations are consistent with the interpretation that exposure of human fibroblasts to low doses of UV induces synthesis of a protein involved in a metabolic pathway that transiently enhances the capacity of cells to repair potentially lethal damage resulting from a subsequent dose of UV.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583677-1065893, http://linkedlifedata.com/resource/pubmed/commentcorrection/6583677-1751, http://linkedlifedata.com/resource/pubmed/commentcorrection/6583677-209462, http://linkedlifedata.com/resource/pubmed/commentcorrection/6583677-375075, http://linkedlifedata.com/resource/pubmed/commentcorrection/6583677-393266, http://linkedlifedata.com/resource/pubmed/commentcorrection/6583677-4318852, http://linkedlifedata.com/resource/pubmed/commentcorrection/6583677-454428, http://linkedlifedata.com/resource/pubmed/commentcorrection/6583677-4570356, http://linkedlifedata.com/resource/pubmed/commentcorrection/6583677-503098, http://linkedlifedata.com/resource/pubmed/commentcorrection/6583677-522880, http://linkedlifedata.com/resource/pubmed/commentcorrection/6583677-6245353, http://linkedlifedata.com/resource/pubmed/commentcorrection/6583677-6248777, http://linkedlifedata.com/resource/pubmed/commentcorrection/6583677-6269150, http://linkedlifedata.com/resource/pubmed/commentcorrection/6583677-6269775, http://linkedlifedata.com/resource/pubmed/commentcorrection/6583677-6281765, http://linkedlifedata.com/resource/pubmed/commentcorrection/6583677-6292708, http://linkedlifedata.com/resource/pubmed/commentcorrection/6583677-6329698, http://linkedlifedata.com/resource/pubmed/commentcorrection/6583677-6814500, http://linkedlifedata.com/resource/pubmed/commentcorrection/6583677-6814522, http://linkedlifedata.com/resource/pubmed/commentcorrection/6583677-6945596, http://linkedlifedata.com/resource/pubmed/commentcorrection/6583677-6947227, http://linkedlifedata.com/resource/pubmed/commentcorrection/6583677-6981460, http://linkedlifedata.com/resource/pubmed/commentcorrection/6583677-7025051, http://linkedlifedata.com/resource/pubmed/commentcorrection/6583677-7031642, http://linkedlifedata.com/resource/pubmed/commentcorrection/6583677-7146111, http://linkedlifedata.com/resource/pubmed/commentcorrection/6583677-740008, http://linkedlifedata.com/resource/pubmed/commentcorrection/6583677-7407188, http://linkedlifedata.com/resource/pubmed/commentcorrection/6583677-795416, http://linkedlifedata.com/resource/pubmed/commentcorrection/6583677-896962
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:volume
81
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
781-4
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Exposure of nondividing populations of primary human fibroblasts to UV (254 nm) radiation induces a transient enhancement in capacity to repair potentially lethal cellular damage.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't